Jdtums.ir: Due to public relations of academic center for education, culture and research (ACECR), simultaneously with research week and year of innovation and flourish, investigators of Iranian Center for Medical Lasers could create a new pain relieving method in painful mucosal lesions as NACLT. In NACLT studies, ICML researchers used CO2 laser in a non-ablative, non-thermal manner to reduce pain immediately and dramatically in a variety painful oral lesions. This procedure was not painful, and anesthesia was not required in any of the patients. There was no visible thermal damage to the oral mucosa, such as ulceration, erosion or even erythema.
At the first stages of these studies, they evaluated the efficacy of a single session NACLT in reducing pain and accelerating the healing process in recurrent aphthous stomatitis. The results of this study showed that NACLT could relieve pain in aphthous ulcers immediately and significantly and accelerate wound healing in these lesions without any visible side effects. The results of different stages of this study were accepted for oral presentation in Laser Florence 2006 international congress and 28th annual conference of the American society for laser in medicine and surgery, Florida, 2008. In addition, the results were published in journal of Lasers in Medical Sciences, 2008.
In the next stages of these studies, for the first time in the world the efficacy of NACLT was evaluated in painful oral mucosal lesions of pemphigus vulgaris by collaboration of dermatologic ward of Imam Khomeini hospital. The results of the pilot study showed that a single session of NACLT could relieve pain in these oral lesions immediately, so that the patients could drink and eat easily. There was no visual effect of damage to the oral mucosa.
One of the other NACLT research projects which is being performed for the first time in the world too, is about using this modality in relieving pain of oral and genital mucosal lesions of behcet’s disease. The primary results of the study showed that NACLT could have very good analgesic effects in these lesions without any visual side effects.
Also NACLT showed an immediate and dramatic relieving pain in patients with oral mucositis after neo-adjuvant chemotherapy.